
Rich in history and art, eastern South Dakota offers endless opportunities for discovery. Just take a drive down I-29 to explore it all.
The main north-south corridor of eastern South Dakota, Interstate 29 passes through charming small towns filled with scenery and culture. Admire the art of Terry Redlin in Watertown, explore the many museums of Brookings, stroll the SculptureWalk in Sioux Falls and marvel at the rare instruments on display at the National Music Museum — just a few of the highlights you’ll see on I-29.
Enter South Dakota on Interstate 29 by heading south from North Dakota to the Sisseton area.
Travel Tip: Held in Agency Village (about 7 miles south of Sisseton), the annual Sisseton-Wahpeton Oyate Wacipi is one of the longest-running powwows in the country.



Drive south one hour (59 miles) to Watertown, a beautiful city with an abundance of outdoor recreation.
Travel Tip: While in Watertown, catch a show or take a fascinating tour of the recently renovated 1889 Goss Opera House.



Continue one hour south to Brookings. It’s the home of South Dakota State University, the largest university in South Dakota.
Travel Tip: Stop by for a scoop of ice cream made on-site at SDSU Dairy Bar.



Made famous in the “Little House on the Prairie” books and TV series, De Smet celebrates the life of the Ingalls family in South Dakota. Note: De Smet is located 40 miles off the interstate, about a 45-minute drive west of Brookings.



Enjoy the vibrant art, culture and cuisine of South Dakota’s largest city, Sioux Falls.
Travel Tip: Levitt at the Falls is a state-of-the-art outdoor music venue on the edges of Falls Park and downtown Sioux Falls. Each summer, the venue hosts 50 free concerts featuring a variety of artists and genres.



Only an hour south on Interstate 29, Vermillion sits atop a bluff of the last natural stretch of the Missouri River.
Travel Tip: Each June, Vermillion hosts the South Dakota Shakespeare Festival. Entertainment includes a full-length production, live music, food and more.



While not directly on I-29, the city of Yankton is well worth a detour. Located 20 miles west of Vermillion, Yankton was the first capital of Dakota Territory, which included Wyoming, Montana and both Dakotas in the 1860s. See a replica of the Dakota Territorial Capitol and learn more state history at the Mead Museum.



More Stops Near Interstate 29 in South Dakota
- South of Vermillion, Elk Point is where you’ll find a campground used by Lewis and Clark on their journey into South Dakota.
- Pay a visit to North Sioux City, the farthest city south on Interstate 29 before crossing the border into Iowa.